The use of the finite element method to wood and wood-based products is fairly recent. Wood is a biomaterial. This involves high variability in its material properties and structure. Moreover, wood is strongly hygroscopic, which impacts its manufacturing processes and its behavior in service. This also involves that most of its material properties vary strongly with moisture content. In this presentation, a few finite element model case studies will be showcased including wood drying and dimensional stability, the hot pressing of medium density fiberboard and the dimensional stability of engineered wood flooring under cyclic relative humidity conditions. The industrial problems, models used and solutions obtained will be presented. The challenges involved in modeling a variable material such as wood will be outlined.