Systèmes dynamiques
Understanding the Pseudomonas aeruginosa ecology in the ICI after an antimicrobial stewardship program
Wu, Jianhong
York University

A relatively simple dynamic model that incorporated several different attributes of an stewardship program(i.e., diminished administration of antimicrobials to uninfected individuals; limited duration of therapy; reduced use of antipseudomonal antimicrobials) was successful in reproducing observed declines in the mean risk of colonization or infection with resistant P. aeruginosa before and after the implementation of an antimicrobial stewardship program. Using this approach we were able to determine the effects of the different elements of the antimicrobial stewardship program and to identify reduced prescribing of antimicrobials as the attribute of an antimicrobial stewardship program that would most substantially reduce antimicrobial resistance in P. aeruginosa in the future.

This is based on a joint work with Amy Hurford (Biology and Mathematics, MUN), Andres Morris (Infectious Disease and Internal Medicine, MSH) and David Fisman (Public Health, Toronto).

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