In this talk, I will report our study of a reaction-diffusion Lyme disease model with seasonality. In the case of a bounded habitat, we obtain a threshold result on the global stability of either disease-free or endemic periodic solution. In the case of an unbounded habitat, we establish the existence of the disease spreading speed and its coincidence with the minimal wave speed for time-periodic traveling wave solutions. We also estimate parameter values based on some published data, and use them to study the Lyme disease transmission in Port Dove, Ontario. Some numerical simulations will present to illustrate our analytic results.