Mathématiques industrielles
Predictive Models of Type 1 Diabetes Progression
Jaberi-Douraki, Majid and Anmar Khadra
Centre of Nonlinear Dynamics, McGill University

The objective of this work is to predict the onset of type 1 diabetes progression by incorporating multiple risk factors such as the interaction of T-cell avidity with autoantibodies. We construct mathematical models in the form of differential equations, of the pathophysiology pertaining to diabetes development to address this issue. The goal is to examine, analytically and numerically, how the binding affinity of autoantibodies correlates with the pathogenic potential of T cells that are reactive to the same autoantigen. Based on our preliminary results, we expect these findings to have significant implications on the stability of autoimmunity and tolerance in the study of this disease.

Mercredi, 19 juin, 16h30
Salle George V